Will Iran Collapse After Khamenei? | US-Iran Story | WW3?

From Cold War alliances to revolutionary enmity, Ambassador Sardar Mus Khan unpacks Iran’s escalating conflict with the US and Israel, revealing a complex web of ideology, proxies, and regional strategy.

The assassination of Iran’s Supreme Leader, Ayatollah Ali Khamenei, has once again thrust the Strait of Hormuz into global focus, igniting fears of a major Middle Eastern escalation. In a recent episode of New Wave History, former Pakistani Ambassador Sardar Masood Khan offered an incisive look into the origins and implications of the region’s intensifying conflict.

Tracing the roots of the crisis, Khan explained that US–Iran relations were once cooperative during the Shah’s rule, with both nations aligned against Soviet communism. However, the 1979 Iranian Revolution dramatically reversed this trajectory, leaving a legacy of resentment against Western powers that endures today. The overthrow of Prime Minister Mohammad Mossadegh in 1953, orchestrated by the US and UK, further embedded Iranian distrust, culminating in decades of enmity between Iran and the United States.

The ambassador highlighted how post-revolution Iran became a perceived existential threat to Israel, particularly due to its support for Hezbollah, Hamas, and regional militias. While Iran insists its nuclear programme remains civilian, Israel and the United States view its missile development and regional influence as direct security threats. The collapse of the 2015 JCPOA agreement, following the US withdrawal in 2018, has only fuelled this escalation, prompting Tehran to expand its uranium enrichment and regional presence.

Khan noted that while proxy networks like Hezbollah and Hamas have been weakened by ongoing conflicts, the current situation marks a departure from indirect engagements to direct military action. Israeli intelligence operations and targeted strikes within Iran demonstrate the high stakes of this confrontation. Meanwhile, Gulf states, despite hosting US bases, are caught between strategic alignment and economic vulnerability, wary of the broader fallout on oil markets and regional stability.

Looking ahead, the ambassador emphasised that Iran’s leadership transition and the potential return of figures like Reza Pahlavi remain unpredictable. Revolutions and uprisings rarely follow linear paths; civil unrest or systemic continuity could shape the geopolitical landscape in unforeseen ways. With multiple global powers watching closely, the Middle East stands at a precarious juncture, where history, ideology, and strategic calculations converge with immediate international consequences.

New Wave History is an educational initiative that seeks to make understanding history easier. It aims to achieve this by fostering a critical perspective on our collective history, and making the main ideas in key historical texts accessible to all, offering explanations and connections that make the past come alive. New Wave History hopes to transform the way people engage with history, by bridging the gap between the academic study of history and our audience. We aim to inspire critical thought and spark curiosity, and fostering a deeper understanding of the events that have shaped our nation and region. New Wave History works in collaboration with New Wave Global, Naya Daur Media, The Friday Times, SAPAN News Network, and other media, research outfits, academic institutions, and civil society groups in South Asia and the United States.