The series is the part of the ICC Women's Championship in which Pakistan currently occupies fifth spot. Australia is the number one side followed by England, India and New Zealand.
Mir took the new ball alongside 17-year-old medium-pacer Fatima Sana and removed four of South Africa's top five inside eight overs.
Mir's four-for, two of which came on back-to-back deliveries in the second over, wrecked the Proteas top order. Coupled with Fatima’s dismissal of Lizelle Lee in the opening over, her demolition job never allowed Africans to recover.
For the hosts, only Mignon du Preez and Chloe Tryon could reach double figures as Nashra Sandhu and Nida Dar cleaned up the rest of the line-up with two wickets a piece.
The start to Pakistan Women's innings was exactly as their South African counterparts' as they lost their opening innings on the third ball of the opening over with just four runs on the board.
However, one-down batter Javeria Khan made sure that that setback did not derail the run chase. Her unbeaten 34-run knock was enough for Pakistan to even absorb the loss of Sidra Ameen (10).
Khan and Bismah Maroof (12*) made sure the team got over the line and register their first-ever victory in South Africa.
Mir was deservedly named the player of the match but she insisted that the result was the product of "a team effort for which everyone tried their hardest".